In a small Brazilian town, there resides an extraordinary duo of identical twins named Elis and Eloá. Their story serves as a beacon of resilience and the remarkable power of the human spirit. Afflicted with Hutchinson-Gilford Progeria Syndrome, a rare and fatal genetic disorder causing accelerated aging, these twins confront their adversities with remarkable grace and strength, earning admiration from people worldwide.
Understanding Hutchinson-Gilford Progeria syndrome
HGPS stands as an exceptionally rare disorder, impacting roughly 1 in 20 million newborns globally. Marked by rapid aging from early childhood, individuals with progeria often display growth delays, diminished body fat and hair, prematurely aged skin, joint stiffness, and severe cardiovascular issues. Typically, those with HGPS have an average life expectancy of about 14.5 years, though some may extend into their late teens or early twenties. This syndrome gained public attention through the film The Curious Case of Benjamin Button.
The condition is caused by a mutation in the LMNA gene, which produces the lamin A protein responsible for maintaining the structural integrity of the cell nucleus. The mutation results in the production of an abnormal version of the protein, called progerin, which causes cells to become unstable and die prematurely.
Elis and Eloá’s journey
Elis and Eloá swiftly captured attention because of their distinctive medical condition. Despite the physical hurdles imposed by progeria, their contagious smiles and steadfast optimism have emerged as beacons of hope and inspiration. Guilherme and Elismar, the twins’ parents, have dedicated their lives to offering the utmost care for their daughters, striving to ensure they experience as normal a life as feasible within the confines of their condition.
The family’s path has been far from easy. Their daily life is filled with demanding medical routines, including physiotherapy, aimed at addressing joint stiffness and preserving mobility. Despite these challenges, Elis and Eloá approach each day with remarkable bravery and an unparalleled enthusiasm for life, which is truly remarkable.
A global community of support
Elis and Eloá’s narrative has touched hearts worldwide, sparking a surge of solidarity from individuals and groups committed to promoting awareness about progeria and backing research endeavors. The Progeria Research Foundation, a pivotal entity in this realm, has played a vital role in propelling research forward and furnishing assistance to families grappling with the condition.
Through social media platforms, the twins’ journey is shared with a broad audience, fostering a sense of community and solidarity. Their family’s updates, documenting both the highs and lows of their daily lives, provide invaluable insights into the realities of living with progeria, while also spreading a message of hope and perseverance.
Advances in research and hope for the future
In recent years, there have been remarkable advancements in comprehending and addressing progeria. A notable milestone occurred in 2020 when the U.S. Food and Drug Administration (FDA) granted approval for the first progeria treatment: lonafarnib. This medication has demonstrated efficacy in prolonging the lives of children with progeria by mitigating the accumulation of progerin in cells, thereby decelerating the disease’s advancement.
Though a cure remains elusive, ongoing research presents promising prospects. Scientists are delving into gene-editing methodologies, like CRISPR, as potential means to rectify the genetic mutation at its root. For families such as Elis and Eloá’s, these breakthroughs offer a ray of hope for the future.
And in our other article, we recounted the remarkable story of a girl born without a nose, affectionately dubbed “Voldemort,” who refuses to let her differences define her.
You Won’t Believe What Happened to Phoebe Cates After ‘Fast Times at Ridgemont High’!
Phoebe Cates starred in many movies, such as “Gremlins” and “Drop Dead Fred,” but she is best known for her famous pool scene in “Fast Times at Ridgemont High” from 1982.
However, Phoebe Cates left Hollywood more than 20 years ago. Nowadays, she has a regular job that she really enjoys.
Phoebe Belle Cates was born on July 16, 1963, in New York City. When she was a young girl, she went to private schools and studied ballet at Juilliard.
Acting was a big part of Phoebe’s family. Her father, Joe Cates, was a producer and director, her uncle was the president of the Director’s Guild, her brother used to be an actor, and her sister, Valerie, worked in theater.
Phoebe wanted to be a dancer when she was younger, but she had to stop after a knee injury.
At 14, Phoebe Cates started modeling and did pretty well. She was even on the cover of Seventeen magazine four times. But she didn’t really enjoy it and wanted to try something new.
“It was just the same thing, over and over. After a while, I did it solely for the money,” Phoebe said about her short modeling career.
One night, at a party at New York’s famous Studio 54, she met her film agent. After that, she trained with Robert Ravan, who founded The Actors’ Circle in New York.
“I just knew that I didn’t want to go to college. I thought if I could get a few movie roles, it would be a great way to avoid college. Seriously, it’s true,” Phoebe told The Daily Item in 1985.
Phoebe also trained with Alice Spivack at the H.B. Studios. She made her acting debut in 1982, playing Sarah in “Paradise.” Less than a year later, she starred in “Experienced” and then “Fast Times at Ridgemont High,” which featured the famous swimming pool scene.
“Fast Times at Ridgemont High” was a big hit with teenagers and became an important part of pop culture. It’s especially famous for one scene that Rolling Stone magazine called “the most memorable bikini-drop in cinema history.”
As a friend of mine said, that scene made a lot of teenage boys’ hearts beat faster than they should have!
In 1982, Phoebe shared her thoughts on acting. “In this business, if a girl wants a career, she has to be willing to strip. If you’ve got a good body, then why not show it?” she said.
“Fast Times at Ridgemont High” had an impressive cast, including future stars like Sean Penn, Jennifer Jason Leigh, Eric Stoltz, and Forest Whitaker.
Jennifer Jason Leigh reflected on the film, saying, “Well, it was a funny thing because we were all so young when we made it. Then it came out and was this big hit. You’d go to the theater, and people would say the lines along with it. People had obviously seen the movie over and over again,” she told The Daily News.
Later on, Phoebe continued working in theater and starred in “Private School” as Christine Ramsey in 1983. She also co-starred in Steven Spielberg’s “Gremlins” in 1984.
Phoebe met Kevin Kline, a well-known theater actor, while auditioning for the 1983 film “The Big Chill.” Although she didn’t get the role, she did meet her future husband.
Kevin was 16 years older than Phoebe, but they didn’t start dating until two years after they first met. Kevin hired Phoebe’s former assistant and asked for help to ask Phoebe out.
In 1989, Phoebe Cates and Kevin Kline got married in New York City when she was 25 and he was 41. They had their first child, Owen Joseph, in 1991 and their daughter, Greta Simone, in 1994.
By 2017, the couple had been married for 27 years, and many people wondered how they stayed so happy together for so long. “We take care of the marriage,” Kline said.
Although Phoebe was successful, she decided to step away from acting after having their children. In the 1990s, she gradually left the entertainment industry.
In 1998, Phoebe told Playboy that she and her husband had agreed to alternate their acting jobs so that their children would always have one parent at home.
Kevin Kline mentioned that even when it was Phoebe Cates’ turn to work, she often chose to stay home with their children. Although she did some acting occasionally, she was more often seen with her husband at red-carpet events, as he continued acting regularly.
In 2005, Phoebe opened a store called Blue Tree near Carnegie Hall. The store sells fragrances, clothing, and gifts.
Phoebe dedicated herself to running the store full-time, often working there personally or searching for new products to sell. Today, you can visit her store at 1283 Madison Avenue in New York City, located on Manhattan’s Upper East Side, where she also lives.
And just so you know, Phoebe still looks amazing!
What do you think of when you hear Phoebe Cates’ name? I always thought she was a pretty good actress, but the first things that come to mind are her shower scene in the cave in “Paradise” and the bikini scene in “Fast Times at Ridgemont High.”
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