The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
13 Years Ago Was the Last Time I Saw My Daughter, Today I Got a Christmas Letter from Her – My Story
Over a decade ago, I lost my job and family because I didn’t take myself seriously. After slowly piecing my life together, I finally have a chance at redemption with my estranged daughter.
I used to be an ambitious young man with the world at my feet. I always saw myself running my own business, and for a while, I believed that I was on the right path. Looking back, I think this passion made my ex-wife, Rebecca, first fall in love with me. She even supported me during the humble beginnings of my old repair shop.
Rebecca and I had our daughter, Harriet, during this time. Unfortunately, my repair shop went bankrupt. I began to feel depressed and lost motivation. I worked as a waiter to make ends meet, but I couldn’t provide a stable lifestyle for my family.
“When are you going to get a real job?” Rebecca asked me. I had no answer. Even though I had a great relationship with Harriet during her childhood, my marriage slowly fell apart.
Rebecca and I fought all the time, and we grew further apart. One day, I was called into the restaurant and told they could no longer keep me on the staff. “We’re going to have to let you go, Jimmy,” my manager told me.
For illustrative purposes only. | Source: Unsplash
At the time, I was at such a low point in my life that I didn’t even care. Perhaps I thought Rebecca could care for me while I looked for a new job. That day I went home and took a walk with my family. Harriet was riding in her little car with foot pedals. Rebecca had a solemn demeanor, and I sensed something was wrong.
“I’m leaving you, Jimmy. I just can’t do this anymore. It’s obvious that you’ve given up on everything,” She told me. In one day, my entire world had come crashing down. I tried to convince Rebecca to give me one more chance, but her mind had already been made up. I gave my daughter a big hug.
“Mom always told me you were a loser and I should forget about you, but I can see that you’ve changed.”
“Daddy will always love you no matter, okay Harriet?” I told her. I could tell that she didn’t understand what was going on. By the following day, Rebecca and Harriet were out of the house, and I was all alone. Rebecca took full custody of our daughter as I was unemployed.
It was only then that I realized how much of a loser I was. I couldn’t even take care of Harriet as I had no savings or job lined up. In what felt like a few months, Rebecca had already moved in with a new partner, Eric. “Until you get your life in order, don’t even think about talking to Harriet,” Rebecca told me.
For illustrative purposes only. | Source: Unsplash
I used the last of my money to buy Harriet a gift for her birthday party, a small bunny rabbit. I also wrote a note which read, “I miss you so much. Happy Birthday. Love Daddy.”
When I reached Eric’s house, I saw he was pretty rich. He had thrown a big birthday party for Harriet, with mascots and a jumping castle. I felt ashamed. My daughter had a new dad. Eric could provide Harriet with things I couldn’t even dream of buying.
I left my gift at their front gate and left. At this point, I was in a very dark place and couldn’t see a way forward. I decided to leave the coast and move cities. All I had to my name was the house my father, Frank, left me.
Since I was flat broke, I sold the house and moved into an apartment in a town in a different state.
I worked odd jobs at times to make a bit of money. Two years after I left my family behind, I was broke again. The following month, I was evicted. I found myself out on the street with nowhere to turn.
For illustrative purposes only. | Source: Unsplash
I can’t keep living like this, I realized. I walked into the local store and begged for a job. The manager recognized me from around town and gave me a chance as a cleaner in the store. In the next few months, I was promoted to cashier, and within a year, I was made administrator of the whole store.
Even though I was finally financially stable and had cleaned up my act, I was still very lonely. Years flew by, and I still wasn’t in contact with any of my family, and I had no real friends. I regularly gave some of my money to charity because I had no one to spend it on.
That all changed today, as for the first time in ages, I received mail that wasn’t an outstanding bill. It was a Christmas letter from Harriet!
For illustrative purposes only. | Source: Unsplash
It has been 13 years since I’ve seen I have seen or heard from my daughter but I’ve been blessed with a Christmas miracle. Her words warmed my heart in a way that I haven’t felt in years. Her letter read:
“Hi, Dad. I’ve finally found you! This may come as a shock, but I’ll be flying in to see you tomorrow. We have so much to talk about. Even though mom and Eric provided me with everything growing up, I always wondered when you would come back.
Mom always told me you were a loser and I should forget about you, but I can see that you’ve changed and got yourself together. Just so you know, I still have the stuffed bunny you left me for my birthday. I named him Jimmy, so in a way, you’ve been with me all along!
See you soon. I love you, and I can’t wait.
Merry Christmas, Dad!”
This is the most incredible day of my life. I’ve missed my daughter so much, and I never thought I’d get this opportunity. I changed my life for the better and did what I could to help my community.
For illustrative purposes only. | Source: Unsplash
Although I felt too ashamed to return home, God has blessed me with a second chance with Harriet. This time, I’ll do everything I can to make her proud and make up for all the time we missed together. After 13 long years, I finally have my shot at redemption.
Have you ever had a moment when you needed to start life with a clean slate? How did you survive it?
Share this story with your friends. It might brighten their day and inspire them.
If you enjoyed this story, you might like this one about a man who abandons his family and is recognized 20 years later begging in the streets by his estranged daughter.
This piece is inspired by stories from the everyday lives of our readers and written by a professional writer. Any resemblance to actual names or locations is purely coincidental. All images are for illustration purposes only. Share your story with us; maybe it will change someone’s life.
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