The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
What Really Happens When You Eat Soaked Almonds Every Morning?
Starting your day with soaked almonds might seem like a small change, but the benefits it offers can truly surprise you! These nutrient-packed nuts, when soaked overnight, become even more powerful, delivering incredible results for your body and mind. Here’s what happens when you make this simple habit a part of your morning routine:
1. Easier Digestion and Nutrient Absorption
When almonds are soaked, their outer skin softens, making them easier to digest. Soaking also activates enzymes that help break down antinutrients like phytic acid, which can otherwise block the absorption of important minerals like calcium, magnesium, and zinc.
Result: Your body gets the full nutritional benefits of almonds, boosting your overall health!
2. Boosted Brain Function
Almonds are rich in Vitamin E, healthy fats, and antioxidants, all of which support brain health. Soaked almonds are also known to contain riboflavin and L-carnitine, which help improve memory and cognitive function.
Result: You’ll feel sharper, more focused, and better equipped to tackle your day.
3. Stronger Bones and Teeth
Packed with calcium, magnesium, and phosphorus, soaked almonds are great for building and maintaining strong bones and teeth. Regular consumption helps reduce the risk of conditions like osteoporosis as you age.
Result: Healthier, stronger bones that support an active lifestyle.
4. Radiant Skin and Healthy Hair
The Vitamin E and antioxidants in soaked almonds work wonders for your skin and hair. They combat free radicals, reduce signs of aging, and promote a natural glow. Plus, the protein and biotin in almonds support healthy, shiny hair.
Result: You’ll look as good as you feel—naturally radiant and vibrant.
5. Controlled Weight and Hunger Cravings
Soaked almonds are a great source of protein and fiber, which help keep you full for longer. They curb unnecessary snacking and regulate hunger levels, making them perfect for weight management.
Result: A steady energy boost without unhealthy cravings.
6. Better Heart Health
Rich in monounsaturated fats, potassium, and magnesium, soaked almonds are excellent for heart health. They help lower bad cholesterol levels, improve blood flow, and reduce the risk of heart disease.
Result: A healthier heart that beats stronger and longer!
How to Soak Almonds
- Take 5-10 raw almonds and soak them in water overnight.
- In the morning, peel off the skin and enjoy them on an empty stomach.
Unbelievable, Right?
Incorporating soaked almonds into your morning routine is a game-changer. From better digestion to glowing skin and a sharper mind, the benefits are endless. So why wait? Start soaking those almonds tonight and let your health transformation begin!
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